![]() Financial Daily from THE HINDU group of publications Wednesday, Jun 12, 2002 |
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Opinion
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Foodgrains Agri-Biz & Commodities - Foodgrains Golden rice: Hope or hype? Syamal Krishna Ghosh
Hybrid rice varieties may be the answer to various nutritional deficiency problems.
NONE of the crops grown today were selected keeping our nutritional requirements in mind. Instead, they were chosen intuitively by our ancestors from the edibles that were found around them. The most important food crop in the developing world rice has no provitamin A and little iron in its endosperm. This has led to horrific problems, such as blindness among children due to Vitamin A deficiency (VAD), and iron-deficiency (anaemia) in nearly a billion women dependent on a rice diet. Biotechnology research has already demonstrated its potential in enhancing the nutritional quality of our food and is also being employed to reduce harmful toxic compounds that exist in our food. The announcement that Swiss scientists had genetically modified a strain of rice to produce beta-carotene a precursor of vitamin A set off heated debate between those who believe this would solve the global problem of VAD and those who argue that such genetically-engineered products might do more harm than good. Neither extreme is tenable. If golden rice and its variants prove safe and effective, it will be a valuable new tool for controlling VAD. The disorders associated with VAD are reduced immune competence (largely from infectious diseases), night blindness, corneal ulcers, keratomalacia and symptoms of xerophthalmia; exacerbation of anaemia through sub-optimal absorption and utilisation of iron; and other conditions not yet fully identified or clarified. VAD was found to increase childhood mortality in populations in which xerophthalmia was not readily recognised because this seemingly mild biochemical deficiency is insufficient to cause xerophthalmia. Diarrhoea, childhood exanthematous diseases and respiratory infections are more common in poor rural populations and further reducing vitamin A absorption increases the mortality rates. Now, there is also more and more evidence that VAD increases the risk of maternal death. It is this health crisis that triggered the development of "Golden Rice".
Vitamin A deficient countries
Clinical and sero-epidemiologic studies and surveys indicate that VAD is widespread throughout the developing world. It has long been recognised in South and South-East Asia (India, Bangladesh, Indonesia, Vietnam, Thailand, and Philippines) by the common presentation of clinical cases of xerophthalmia (night blindness to permanently blinding). Subsequently, in Africa also, it is found that a large proportion of pediatric blindness was due to acute deterioration in vitamin A status during childhood.
How VAD develops
It is critical to ensuring that children, particularly infants, receive the right balance of nutrients needed to grow up healthy and strong. However, parents in developing countries do not have the resources for balanced diet, and lack of it is more in many cases, which results in VAD. Children begin life with an urgent need for vitamin A. Even those of wellnourished mothers babies born with barely enough vitamin A to sustain them during the first phase of life. In the developing countries children consume vitamin A-deficient diet throughout life, not only during early infancy. Though people can receive abundant vitamin A from animal products such as eggs, butter, cheese etc., poor rural population depends on beta-carotene found in dark-green leafy vegetables, carrots and fruits. On the other hand, these leafy vegetables are poor substitutes of vitamin A compared to animal sources of the preformed vitamin.
Strategies to control VAD
In the developing world, every year, 11.3 million children below five years die, more than six million of them are directly or indirectly malnourished. Ensuring enough vitamin A to these children can increase their chances of survival as vitamin A is essential for the immune system to function properly and it improves resistance to disease and plays a vital role in their growth and development. Today, the world must take initiative to eliminate VAD by taking it as a principal element of health problem for children in high-risk areas. Three basic strategies exist for increasing vitamin A intake:
There were lingering concerns about the safety and efficacy of vitamin A supplementation and about safe dosage levels for various age groups. Capsule supplementation and food fortification are among the cost-effective, safe and sustainable ways to improve children's health and chances of survival. Yet these measures are being taken in far too few countries, and many countries have not yet realised they have a VAD problem.
Dietary diversification
The logical solution to vitamin A deficiency is to increase the consumption of natural dietary sources of vitamin A, which can be achieved through traditional food sources, particularly those available to poor, rural, high-risk populations. Vulnerable children can consume sufficient quantities of dark-green leafy vegetables to normalise their vitamin A status. Adults may be able to obtain sufficient vitamin A by consuming larger amounts of vegetables and fruits than what children consume through diet diversification.
Golden rice
Golden rice, the product of genetic modification of rice is claimed to be developed to address the VAD problem of the developing world. Golden rice contains betacarotene. It has created lot of hopes and hypes across the globe and there is criticism about its efficacy and ability to serve the said purpose.
For golden rice to hit the market,
According to Rockefeller Foundation (RFF), "Golden rice'' promises to be a major breakthrough in the prevention of childhood blindness, and to reverse this alarming trend in global health. The primary aim of its inventors, Profs Ingo Protrykus and Peter Beyer, was to produce rice with enhanced beta-carotene and other carotenoids the body uses to convert into vitamin A. This is critical, as unmilled brown rice contains a negligible amount of betacarotene. Advances in biotechnology ensure that golden rice will be available to deliver these vital, life-saving nutrients. From the outset, its inventors were determined to see that this technology reached those who needed it most, quickly, safely and efficiently. At the same time, Syngenta will explore commercial opportunities for sale of golden rice into the expanding market for healthy foods in more developed countries, with particular focus on Japan and North America. Syngenta will also be providing regulatory, advisory and research expertises to assist in making golden rice readily available among developing nations. As many experts agree, from researchers to health-care and nutrition specialists, golden rice is an exciting and potentially revolutionary development, one that could make a lasting difference for literally millions of malnourished, children across the globe. A decade ago, the public health organisations recognised to improve the vitamin A status of young children throughout the developing world. Although more than 70 countries have embraced the global goal of eliminating VAD as a public health problem, progress has been slow, largely because of the costs and logistical challenges to changing diets, delivering large-dose supplements regularly, and fortifying traditional dietary items. A number of bilateral and international agencies recently recommitted themselves to these efforts, even as continuing research expands the implications of deficiency. New tools such as genetically modified staple crops could provide important strategies and stimulate these global efforts. Biotechnology has often been criticised for only benefiting farmers and not the people who actually eat the food. But a new product golden rice has the potential to change that. Adding nutrient to rice has the potential to save millions of lives. Green revolution lifted millions of farmers from poverty and brought reasonable food security despite the massive population increase during this period. But still there are millions of hungry people in the world. Golden rice and other biotech products can provide an additional choice for the willing consumers and help millions of marginalised people and farmers without much extra cost. There is nothing as 100 per cent safe food, and it never has been. Trace levels of thousands of toxicants and chemicals are present in everything we eat, which are shown to be carcinogenic or hazardous with huge doses. Anxiety over this GM food is understandable, which includes consumer unfamiliarity, lack of reliable information on the biosafety concerns, a steady negative opinion in the media, opposition by activist groups, growing mistrust of industry and lack of awareness on food production systems. The scientific community has neither adequately addressed public concerns about GM foods nor effectively communicated the value of this technology. If biotech products have met the highly rigorous and stringent standards of FDA, EPA and USDA in the US, and elsewhere, how can it be more riskier and hazardous in the developing countries, where food safety standards are relatively much less? Clearly, societal acceptance is pivotal to the continued development and application of biotechnology in food and agriculture. It is common to generate an exaggerated fear of new innovations while perceiving older or 'natural' products as always more benign. There are claims that agricultural biotechnological advancements and products are only for profit and monopoly by MNC. But can anybody say that it will not benefit the farmer or customer? Though golden rice is not the only solution to malnutrition, it should be considered as an attempt to benefit the mankind and society as whole. (The author is with Nagarjuna Agricultural Research and Development Institute, Hyderabad. His views are personal.)
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